Spinal muscular atrophy (SMA), also called autosomal recessive proximal spinal muscular atrophy and 5q spinal muscular atrophy in order to distinguish it from Nusinersen · Hyporeflexia · Spinal muscular atrophies. Spinal muscular atrophy with progressive myoclonic epilepsy (SMA -PME), sometimes called Jankovic–Rivera syndrome, is a very rare neurodegenerative. Nusinersen (INN), marketed as Spinraza, is the first drug approved by the U.S. In , the spinal muscular atrophy disease-causing gene, termed the survival motor neuron (SMN), was discovered. Each individual has 2 SMN genes, SMN1. Werdnig-Hoffman disease, which is also known as spinal muscular atrophy type 1 (SMA1) or acute spinal muscular atrophy, refers to. Spinal muscular atrophies (SMAs) are a genetically and clinically.